In Vs System 2PCG, players choose a main character, build a deck with exactly sixty cards, and attempt to KO the other player's main character in a game of superhero battles.

Vs System 2PCG: New Mutants showcases the cast of the nostalgic New Mutants comics and introduces new mechanics, Main Characters, Supporting Characters, Plot Twists, and Locations. Vs System 2PCG: SHIELD vs Hydra can be combined with any other Vs System 2PCG sets. A single box contains a full play-set of all cards.